Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural insights into triglyceride storage mediated by fat storage-inducing transmembrane (FIT) protein 2.

PloS one - 24 May 2010

Gross David A, Snapp Erik L, Silver David L

Abstract excerpt

Fat storage-Inducing Transmembrane proteins 1 & 2 (FIT1/FITM1 and FIT2/FITM2) belong to a unique family of evolutionarily conserved proteins localized to the endoplasmic reticulum that are involved in triglyceride lipid droplet formation. FIT proteins have been shown to mediate the partitioning o...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Conserved Sequence
Share to Fluorescent Antibody Technique
Share to Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Molecular

Share to Mutant Proteins

Share to Protein Structure, Tertiary

Share to Structure-Activity Relationship

Share to Triglycerides

Source

Open in PubMed Open full text

Identifiers

PMID: 20520733
DOI: 10.1371/journal.pone.0010796
PMCID: PMC2875400

Genes

FITM1
FITM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20520733-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural insights into triglyceride storage mediated by fat storage-inducing transmembrane (FIT) protein 2.PMID 20520733Read ↗

Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation.Semantic proximity Read ↗

FITM2 deficiency results in ER lipid accumulation, ER stress, reduced apolipoprotein B lipidation, and VLDL triglyceride secretion <i>in vitro</i> and in mouse liverSemantic proximity Read ↗

Destabilization of β Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes.Semantic proximity Read ↗

Lipase maturation factor LMF1, membrane topology and interaction with lipase proteins in the endoplasmic reticulum.Semantic proximity Read ↗

TM6SF2 binds cholesterol, interacts with apolipoprotein B, and promotes hepatic lipid secretionSemantic proximity Read ↗

Identification of diverse lipid droplet targeting motifs in the PNPLA family of triglyceride lipases.Semantic proximity Read ↗

Comparative study of Dog and Human Lipid Droplet-associated protein (PLIN2)Semantic proximity Read ↗

A system-wide analysis of lipid transfer proteins delineates lipid mobility in human cellsSemantic proximity Read ↗

Concept of lipid droplet biogenesisSemantic proximity Read ↗

Amphipathic Helices Enable Fatty Acid Uptake and Activation by Human FATP2 at ER Contact SitesSemantic proximity Read ↗

Lipase maturation factor 1: structure and role in lipase folding and assembly.Semantic proximity Read ↗

Mutational scanning pinpoints distinct binding sites of key ATGL regulators in lipolysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.