Article

Precise manipulation of site and stoichiometry of capsid modification enables optimization of functional adeno-associated virus conjugates

2023-09-07

Abstract excerpt

The ability to engineer adeno-associated virus (AAV) vectors for targeted infection of specific cell types is critically important to fully harness its potential of human gene therapy. A promising approach to achieve this objective involves chemically attaching retargeting ligands onto the virus capsid. Site-specific incorporation of a bioorthogonal noncanonical amino acid (ncAA) into the AAV capsid proteins provi...

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Literature Corpus work: 32d48ce8-f36e-5373-95ab-c7621a289b7a
DOI: 10.1101/2023.09.07.556719

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