Article
Site-Specific PEGylated Adeno-Associated Viruses with Increased Serum Stability and Reduced Immunogenicity.
Molecules (Basel, Switzerland) - 11 Jul 2017
Yao Tianzhuo, Zhou Xueying, Zhang Chuanling, Yu Xiaojuan, Tian Zhenyu, Zhang Lihe, Zhou Demin
Abstract excerpt
Adeno-associated virus (AAV) is one of the most extensively studied and utilized viral vectors in clinical gene transfer research. However, the serum instability and immunogenicity of AAV vectors significantly limit their application. Here, we endeavored to overcome these limitations by developing a straightforward approach for site-specific PEGylation of AAV via genetic code expansion. This technique includes...
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