Article

A facile chemical strategy to synthesize precise AAV-protein conjugates for targeted gene delivery

2024-07-20

Abstract excerpt

The efficacy of current gene therapy approaches using adeno associated virus (AAV) vectors is limited by the poor control over their tissue tropism. Untargeted AAV vectors require high doses to achieve therapeutic efficacy, which is associated with toxic off-target impacts and increased therapeutic costs. The ability to reprogram existing AAV vectors to selectively transduce target tissues is essential to develop...

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Literature Corpus work: f6c0848e-d0a7-5444-823b-9ae090fc96ee
DOI: 10.1101/2024.07.20.604406

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