Article

A Highly Conserved 3 <sub>10</sub> -Helix Within the Kinesin Motor Domain is Critical for Kinesin Function and Human Health

2020-09-22

Abstract excerpt

KIF1A, a kinesin-3 family member, plays critical roles as a long-distance cargo-transporter within neurons. Over 100 known KIF1A mutations in humans result in KIF1A Associated Neurological Disease (KAND), developmental and degenerative neurological conditions for which there is no cure. A de novo missense mutation, P305L, was recently identified in several children diagnosed with KAND, but the underlying molecula...

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Literature Corpus work: f37ba47e-d523-5040-b5e7-bacf211e139e
DOI: 10.1101/2020.09.22.308320

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