Article

HIFα isoform specific activities drive cell-type specificity of <i>VHL</i> -associated oncogenesis

2024-12-03

Abstract excerpt

Cancers arising from dysregulation of generally operative signaling pathways are often tissue specific, but the mechanisms underlying this paradox are poorly understood. Based on striking cell-type specificity, we postulated that these mechanisms must operate early in cancer development and set out to study them in a model of von Hippel Lindau (VHL) disease. Biallelic mutation of the VHL ubiquitin ligase leads to...

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Literature Corpus work: 32b27f33-f9c5-53b7-b429-5a71c0b64455
DOI: 10.1101/2024.11.28.625663

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