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Article

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

Molecular and cellular biology - 1 Jul 2005

Raval Raju R, Lau Kah Weng, Tran Maxine G B, Sowter Heidi M, Mandriota Stefano J, Li Ji-Liang, Pugh Christopher W, Maxwell Patrick H, Harris Adrian L, Ratcliffe Peter J

Abstract excerpt

Defective function of the von Hippel-Lindau (VHL) tumor suppressor ablates proteolytic regulation of hypoxia-inducible factor alpha subunits (HIF-1alpha and HIF-2alpha), leading to constitutive activation of hypoxia pathways in renal cell carcinoma (RCC). Here we report a comparative analysis of the functions of HIF-1alpha and HIF-2alpha in RCC and non-RCC cells. We demonstrate common patterns of HIF-alpha...

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Identifiers

PMID: 15964822
DOI: 10.1128/MCB.25.13.5675-5686.2005
PMCID: PMC1157001

Genes

VHL

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Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.PMID 15964822Read ↗

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