Article
Haploinsufficiency in tumor predisposition syndromes: altered genomic transcription in morphologically normal cells heterozygous for VHL or TSC mutation.
Oncotarget - 14 Mar 2017
Peri Suraj, Caretti Elena, Tricarico Rossella, Devarajan Karthik, Cheung Mitchell, Sementino Eleonora, Menges Craig W, Nicolas Emmanuelle, Vanderveer Lisa A, Howard Sharon, Conrad Peggy, Crowell James A, Campbell Kerry S, Ross Eric A, Godwin Andrew K, Yeung Anthony T, Clapper Margie L, Uzzo Robert G, Henske Elizabeth P, Ricketts Christopher J, Vocke Cathy D, Linehan W Marston, Testa Joseph R, Bellacosa Alfonso, Kopelovich Levy, Knudson Alfred G
Abstract excerpt
Tumor suppressor genes and their effector pathways have been identified for many dominantly heritable cancers, enabling efforts to intervene early in the course of disease. Our approach on the subject of early intervention was to investigate gene expression patterns of morphologically normal "one-hit" cells before they become hemizygous or homozygous for the inherited mutant gene which is usually required for...
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