Article
Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells.
The Journal of biological chemistry - 7 Nov 2003
Gunaratnam Lakshman, Morley Melissa, Franovic Aleksandra, de Paulsen Natalie, Mekhail Karim, Parolin Doris A E, Nakamura Eijiro, Lorimer Ian A J, Lee Stephen
Abstract excerpt
Bi-allelic-inactivating mutations of the VHL tumor suppressor gene are found in the majority of clear cell renal cell carcinomas (VHL(-/-) RCC). VHL(-/-) RCC cells overproduce hypoxia-inducible genes as a consequence of constitutive, oxygen-independent activation of hypoxia inducible factor (HIF). While HIF activation explains the highly vascularized nature of VHL loss lesions, the relative role of HIF in...
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