Article

Human SEC23B-deficient hematopoietic stem cell model of CDAII recapitulates erythroid and cell-cycle defects

2026-07-02

Abstract excerpt

<title>Abstract</title> <p>Background: Congenital dyserythropoietic anemia type II (CDAII) is an inherited disorder affecting red blood cell development. It is caused by mutations in the SEC23B gene, which causes protein hypoglycosylation and morphological alterations in erythroid cells, such as the presence of binucleated erythroblasts in the patient’s bone marrow. Patients with CDAII suffer from anemia of varyi...

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Literature Corpus work: 99d0aabf-7ac2-5195-85d7-582d8e9527e7
DOI: 10.21203/rs.3.rs-10083063/v1

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