Article

Comparison of the Amyloid Plaque Proteome in Down Syndrome, Early-Onset Alzheimer’s Disease and Late-Onset Alzheimer’s Disease

2024-07-15

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> Down syndrome (DS) is strongly associated with Alzheimer’s disease (AD), attributable to <italic>APP</italic> overexpression. DS exhibits Amyloid-β (Aβ) and Tau pathology similar to early-onset AD (EOAD) and late-onset AD (LOAD). The study aimed to evaluate the Aβ plaque proteome of DS, EOAD and LOAD.<bold>Methods</bold> Using unbiased localized proteomics, we an...

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Literature Corpus work: 8fe5d635-e7de-5899-96e3-688413b8cc65
DOI: 10.21203/rs.3.rs-4469045/v1

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