Article

Adaptive Evolution of Peptide Inhibitors for Mutating SARS-CoV-2

2020-07-09

Abstract excerpt

The SARS-CoV-2 virus is currently causing a worldwide pandemic with dramatic societal consequences for the humankind. In the last decades, disease outbreaks due to such zoonotic pathogens have appeared with an accelerated rate, which calls for an urgent development ofadaptive (smart) therapeutics. Here, we develop a computational strategy to adaptively evolve peptides that could selectively inhibit mutating S prot...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 326859a9-3f9e-59e8-8eb4-53a673fb335d
DOI: 10.26434/chemrxiv.12622667.v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Adaptive Evolution of Peptide Inhibitors for Mutating SARS-CoV-2DOI 10.26434/chemrxiv.12622667.v2Read

DNA aptamers masking angiotensin converting enzyme 2 as an innovative way to treat SARS-CoV-2 pandemic.Semantic proximity Read

De novo selected hACE2 mimics that integrate hotspot peptides with aptameric scaffolds for binding tolerance of SARS-CoV-2 variantsSemantic proximity Read

SARS-CoV-2 variants infectivity prediction and therapeutic peptide design using computational approaches.Semantic proximity Read

Computational Design of Stapled Peptide Inhibitor against SARS-CoV-2 Receptor Binding DomainSemantic proximity Read

Computational optimization of the SARS-CoV-2 receptor-binding-motif affinity for human ACE2Semantic proximity Read

Targeting SARS-CoV-2 Receptor Binding Domain with Stapled Peptides: An In Silico StudySemantic proximity Read

Computational insights and impact of combinatorial peptidomimetics on immune escape SARS-CoV-2 variants.Semantic proximity Read

Identification of Potential ACE2-Derived Peptide Mimetics in SARS-CoV-2 Omicron Variant Therapeutics using Computational Approaches.Semantic proximity Read

Modeling Substrate Coordination to Zn-Bound Angiotensin Converting Enzyme 2Semantic proximity Read

<i>De novo</i> design of ACE2 protein decoys to neutralize SARS-CoV-2Semantic proximity Read

Machine Learning Driven Simulations of the SARS-CoV-2 Fitness Landscape from Deep Mutational Scanning ExperimentsSemantic proximity Read

Adaptive inhibitors of the HIV-1 protease.Semantic proximity Read