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Article

DNA aptamers masking angiotensin converting enzyme 2 as an innovative way to treat SARS-CoV-2 pandemic.

Pharmacological research - 1 Jan 2022

Villa Alessandro, Brunialti Electra, Dellavedova Jessica, Meda Clara, Rebecchi Monica, Conti Matteo, Donnici Lorena, De Francesco Raffaele, Reggiani Angelo, Lionetti Vincenzo, Ciana Paolo

Abstract excerpt

All the different coronavirus SARS-CoV-2 variants isolated so far share the same mechanism of infection mediated by the interaction of their spike (S) glycoprotein with specific residues on their cellular receptor: the angiotensin converting enzyme 2 (ACE2). Therefore, the steric hindrance on this cellular receptor created by a bulk macromolecule may represent an effective strategy for the prevention of the viral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34798263
DOI: 10.1016/j.phrs.2021.105982
PMCID: PMC8594078

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