Article

Modeling Substrate Coordination to Zn-Bound Angiotensin Converting Enzyme 2

2021-03-29

Abstract excerpt

<h4>ABSTRACT</h4> The spike protein in the envelope of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interacts with the receptor Angiotensin Converting Enzyme 2 (ACE2) on the host cell to facilitate the viral uptake. Angiotensin II (Ang II) peptide, which has a naturally high affinity for ACE2, may be useful in inhibiting this interaction. In this study, we computationally designed several Ang II m...

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Literature Corpus work: 47f5453f-f511-5713-9852-fd39bb09cfcf
DOI: 10.1101/2021.03.27.437352

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