Article

Computational optimization of the SARS-CoV-2 receptor-binding-motif affinity for human ACE2

2020-07-20

Abstract excerpt

<h4>ABSTRACT</h4> The coronavirus SARS-CoV-2, that is responsible for the COVID-19 pandemic, and the closely related SARS-CoV coronavirus enter cells by binding at the human angiotensin converting enzyme 2 (hACE2). The stronger hACE2 affinity of SARS-CoV-2 has been connected with its higher infectivity. In this work, we study hACE2 complexes with the receptor binding domains (RBDs) of the human SARS-CoV-2 and hum...

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Literature Corpus work: 8ef60c4e-e4f6-5e4f-bb5d-ac22c8cad776
DOI: 10.1101/2020.07.20.212068

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