Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting SARS-CoV-2 Receptor Binding Domain with Stapled Peptides: An In Silico Study

11 Jun 2021

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into a pandemic of unprecedented scale. This coronavirus enters cells by the interaction of the receptor binding domain (RBD) with the human angiotensin-converting enzyme 2 receptor (hACE2). In this study, we employed a rational structure-based design to propose 22-mer stapled peptides using the structure of the hACE2 α1 helix as a template....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computational Drug Discovery Methods
Share to Influenza Virus Research Studies
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34114829
DOI: 10.1021/acs.jpcb.1c02398

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting SARS-CoV-2 Receptor Binding Domain with Stapled Peptides: An In Silico StudyPMID 34114829Read ↗

Computational Design of Stapled Peptide Inhibitor against SARS-CoV-2 Receptor Binding DomainSemantic proximity Read ↗

Inhibition of SARS-CoV-2 pathogenesis by potent peptides designed by the mutation of ACE2 binding region.Semantic proximity Read ↗

Antiviral Peptides as Promising Therapeutics against SARS-CoV-2Semantic proximity Read ↗

SARS-CoV-2 variants infectivity prediction and therapeutic peptide design using computational approaches.Semantic proximity Read ↗

DNA aptamers masking angiotensin converting enzyme 2 as an innovative way to treat SARS-CoV-2 pandemic.Semantic proximity Read ↗

Computational optimization of the SARS-CoV-2 receptor-binding-motif affinity for human ACE2Semantic proximity Read ↗

A novel peptide analogue of spike glycoprotein shows antiviral properties against SARS-CoV-2: An in silico approach through molecular docking, molecular dynamics simulation and MM-PB/GBSA calculationsSemantic proximity Read ↗

E484K mutation in SARS-CoV-2 RBD enhances binding affinity with hACE2 but reduces interactions with neutralizing antibodies and nanobodies: Binding free energy calculation studies.Semantic proximity Read ↗

E484K mutation in SARS-CoV-2 RBD enhances binding affinity with hACE2 but reduces interactions with neutralizing antibodies and nanobodies: Binding free energy calculation studiesSemantic proximity Read ↗

Interactions of the Receptor Binding Domain of SARS-CoV-2 Variants with hACE2: Insights from Molecular Docking Analysis and Molecular Dynamic SimulationSemantic proximity Read ↗

De novo selected hACE2 mimics that integrate hotspot peptides with aptameric scaffolds for binding tolerance of SARS-CoV-2 variantsSemantic proximity Read ↗

Designing peptides predicted to bind to the omicron variant better than ACE2 via computational protein design and molecular dynamics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.