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Article

Atypical behavior of recurrent glioblastoma tumor cells with a highly adherent radial glial phenotype.

CNS oncology - 1 Dec 2025

Vaidya Manjusha, Smith Jonhoi, Pessaia Julia, Field Melvin, Sugaya Kiminobu

Abstract excerpt

Glioblastoma (GBM) is the most common malignant primary brain tumor, characterized by a high recurrence rate despite aggressive therapy. We present a case of a 32-year-old male with a recurrent WHO Grade IV IDH1-mutant astrocytoma after undergoing standard Stupp protocol chemoradiation and tumor-treating field therapy. Repeat surgery was performed where in vitro analysis of recurrent GBM cells revealed atypical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40971175
DOI: 10.1080/20450907.2025.2559576
PMCID: PMC12452472

Genes

IDH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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