Article
Integrated neoantigen and immune cell profiling of POLε-mutant colorectal tumors reveals distinct immune sub-types
2025-09-02
Abstract excerpt
<title>Abstract</title> <p>Colorectal cancer (CRC) is a common and highly heterogeneic tumor. Mutations that occur within the DNA polymerase epsilon (POLε) gene greatly diminish the polymerase proofreading function and occur in a subset of CRC. These POLε mutations result in errors during DNA replication and result in elevated levels of tumor mutational burden (TMB) and genome instability. Despite these features,...
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Identifiers and source
- Literature Corpus work
- 325ac57e-ba09-545c-903a-1f6e4531e006
- DOI
- 10.21203/rs.3.rs-7245242/v1