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AI-Driven Prediction Unveils SMAD4-Specific HLA-Restricted Epitopes: A Novel Therapeutic Target for Precision Treatment of Peritoneal Metastasis in Colorectal Cancer

2025-08-14

Abstract excerpt

<title>Abstract</title> <p>Background Peritoneal metastasis (CRC-PM), a lethal feature of advanced colorectal cancer, lacks effective treatments. Neoantigen-based immunotherapy has emerged as a promising therapeutic strategy for metastatic CRC. Methods Multi-omics including TIMER and TISIDB tools, two computational pipelines of NetMHCpan and GenoImmune's artificial intelligence (AI)-driven Neoantigen Techonology...

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Literature Corpus work: 7d55b807-963f-5eb1-ab42-0b5a119e943b
DOI: 10.21203/rs.3.rs-7066314/v1

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