Article

Defective insulin clearance plays a primary role in the pathogenesis of chronic kidney disease in mice with null deletion of <i>Ceacam2</i> gene

2025-11-26

Abstract excerpt

Endogenous insulin clearance occurs primarily in hepatocytes and to a lower extent in kidney’s proximal tubule cells (KPTCs). CEACAM1 promotes receptor-mediated insulin uptake to be degraded in hepatocytes in a phosphorylation-dependent manner. Its deletion/inactivation causes hyperinsulinemia-driven insulin resistance, steatohepatitis and liver fibrosis. CEACAM2, the dominant CEACAM protein in murine KPTCs, share...

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Literature Corpus work: 3226f136-50c3-59ac-96d0-31ef6e5f8ef3
DOI: 10.1101/2025.11.23.690002

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