Article
Carcinoembryonic antigen-related cell adhesion molecule 2 controls energy balance and peripheral insulin action in mice.
Gastroenterology - 1 Aug 2010
Heinrich Garrett, Ghosh Sumona, Deangelis Anthony M, Schroeder-Gloeckler Jill M, Patel Payal R, Castaneda Tamara R, Jeffers Shane, Lee Abraham D, Jung Dae Young, Zhang Zhiyou, Opland Darren M, Myers Martin G, Kim Jason K, Najjar Sonia M
Abstract excerpt
BACKGROUND & AIMS: The carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a transmembrane glycoprotein with pleotropic functions, including clearance of hepatic insulin. We investigated the functions of the related protein CEACAM2, which has tissue-specific distribution (kidney, uterus, and crypt epithelia of intestinal tissues), in genetically modified mice. METHODS: Ceacam2-null mice...
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