Insulin‐like growth factor‐ II is produced by, signals to and is an important survival factor for the mature podocyte in man and mouse

Abstract excerpt

Podocytes are crucial for preventing the passage of albumin into the urine and, when lost, are associated with the development of albuminuria, renal failure and cardiovascular disease. Podocytes have limited capacity to regenerate, therefore pro-survival mechanisms are critically important. Insulin-like growth factor-II (IGF-II) is a potent survival and growth factor; however, its major function is thought to be...

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