Article

Nuclear deformation and anchorage defect induced by DCM mutants in lamin A

2019-04-16

Abstract excerpt

<h4>ABSTRACT</h4> Dilated Cardiomyopathy (DCM) is one of the different types of laminopathies caused by the mutations in A-type lamins in somatic cells. The involuntary cyclic stretching of cardiac muscle cells, as observed in normal physiological conditions is perturbed in DCM which afflict patients globally. As A-type lamins are principal components in nuclear mechanics, we have investigated the effect of the D...

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Literature Corpus work: 32114907-6588-592d-9a7a-edfca0af4ad7
DOI: 10.1101/611665

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