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Article

Biomechanical defects and rescue of cardiomyocytes expressing pathologic nuclear lamins.

Cardiovascular research - 1 May 2018

Laurini Erik, Martinelli Valentina, Lanzicher Thomas, Puzzi Luca, Borin Daniele, Chen Suet Nee, Long Carlin S, Lee Patrice, Mestroni Luisa, Taylor Matthew R G, Sbaizero Orfeo, Pricl Sabrina

Abstract excerpt

Aims: Given the clinical impact of LMNA cardiomyopathies, understanding lamin function will fulfill a clinical need and will lead to advancement in the treatment of heart failure. A multidisciplinary approach combining cell biology, atomic force microscopy (AFM), and molecular modeling was used to analyse the biomechanical properties of human lamin A/C gene (LMNA) mutations (E161K, D192G, N195K) using an in vitro...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Elastic Modulus

Share to Lamin Type A

Share to Microscopy, Atomic Force

Share to Myocardial Contraction

Share to p38 Mitogen-Activated Protein Kinases

Share to Protein Conformation, alpha-Helical

Source

Open in PubMed Open full text

Identifiers

PMID: 29432544
DOI: 10.1093/cvr/cvy040
PMCID: PMC5909658

Genes

LMNA
AFM

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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