Article

Defects in lamin A-Prohibitin crosstalk lead to ROS elevation and OxPhos imbalance in laminocardiomyopathy

2025-07-21

Abstract excerpt

Lamins are critical for maintaining nuclear homeostasis, chromosome positioning, and cellular mechanotransduction, which involves the transfer of mechanical signals from the cellular microenvironment to the nucleus. Recent studies have also highlighted the involvement of lamin A in mitochondrial homeostasis and the regulation of reactive oxygen species production. Missense mutations in lamin A are linked to a spec...

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Literature Corpus work: dd0a2060-244e-5f08-8633-cda88ab464a2
DOI: 10.1101/2025.07.17.665267

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