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Article

Systemic brain-body metabolic coupling patterns in amyotrophic lateral sclerosis: a whole-body [18F] fluorodeoxyglucose PET/CT study across clinical phenotypes.

European journal of nuclear medicine and molecular imaging - 1 May 2026

Hou Manliu, Xie Xin, Hu Jirong, Rominger Axel, Shi Kuangyu, Xiao Ling, Tang Yongxiang, Hu Shuo

Abstract excerpt

PURPOSE: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder involving both central and peripheral systems. Its marked heterogeneity and variable prognosis suggest pathophysiology beyond motor neuron degeneration. This study aimed to map brain–body metabolic networks using whole-body [18F]FDG PET/CT, characterize systemic remodeling, and to identify clinically meaningful brain-organ...

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PMID: 41588209
DOI: 10.1007/s00259-026-07765-x

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