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Article

Progressive Thalamo-Cortical Disconnection in Amyotrophic Lateral Sclerosis Genotypes: Structural Degeneration and Network Dysfunction of Thalamus-Relayed Circuits.

European journal of neurology - 1 May 2025

Tahedl Marlene, Kleinerova Jana, Doherty Mark A, Hengeveld Jennifer C, McLaughlin Russell L, Hardiman Orla, Tan Ee Ling, Bede Peter

Abstract excerpt

BACKGROUND: The thalamus is a key subcortical hub of numerous corticobasal and corticocortical circuits mediating a wealth of cognitive, behavioural, sensory and motor processes. While thalamic pathology is increasingly recognised in amyotrophic lateral sclerosis, its degeneration is often assessed in isolation instead of adopting a network-wise perspective and assessing the integrity of its rich cortical...

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Identifiers

PMID: 40346885
DOI: 10.1111/ene.70146
PMCID: PMC12064938

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ATXN2

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