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Article

Methylation-based reclassification and risk stratification of skull-base chordomas

11 Nov 2022

Abstract excerpt

Background: Skull-base chordomas are rare malignant bone cancers originating from the remnant of the notochord. Survival is variable, and clinical or molecular factors cannot reliably predict their outcomes. This study therefore identified epigenetic subtypes that defined new chordoma epigenetic profiles and their corresponding characteristics. Methods: Methylation profiles of 46 chordoma-resected neoplasms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36439461
DOI: 10.3389/fonc.2022.960005

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