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Article

Chordoma: Genetics and Contemporary Management.

International journal of molecular sciences - 28 May 2024

Desai Rupen, Pelargos Panayiotis E, Dunn Ian F

Abstract excerpt

Chordomas, arising from notochord remnants, are rare neoplasms with aggressive growth patterns despite their histologically low-grade nature. This review explores their embryological origins, molecular markers like brachyury, and genetic alterations driving pathogenesis. Diagnosis relies on advanced imaging and biopsy confirmation due to overlapping features with chondrosarcoma. The WHO classification...

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Identifiers

PMID: 38892063
DOI: 10.3390/ijms25115877
PMCID: PMC11172617

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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