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Article

Translation of HIV-1 unspliced RNA is regulated by 5' untranslated region structure.

Journal of virology - 22 Oct 2024

Cheng Zetao, Islam Saiful, Kanlong Joseph G, Sheppard Madeline, Seo Heewon, Nikolaitchik Olga A, Kearse Michael G, Pathak Vinay K, Musier-Forsyth Karin, Hu Wei-Shau

Abstract excerpt

HIV-1 must generate infectious virions to spread to new hosts and HIV-1 unspliced RNA (HIV-1 RNA) plays two central roles in this process. HIV-1 RNA serves as an mRNA that is translated to generate proteins essential for particle production and replication, and it is packaged into particles as the viral genome. HIV-1 uses several transcription start sites to generate multiple RNAs that differ by a few nucleotides...

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Identifiers

PMID: 39315813
DOI: 10.1128/jvi.01160-24
PMCID: PMC11494990

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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