Article

HIV-1 single transcription start site mutants display complementary replication functions that are restored by reversion

2024-12-04

Abstract excerpt

HIV-1 transcription initiates at two positions, generating RNAs with either cap 1G or cap 3G 5′ ends. The replication fates of these RNAs differ, with viral particles encapsidating almost exclusively cap 1G RNAs and cap 3G RNAs retained in cells where they are enriched on polysomes and among spliced viral RNAs. Here, we studied replication properties of virus promoter mutants that produced only one RNA 5′ isof...

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Literature Corpus work: 211e66b3-c3af-58e4-aad6-ee27ef881c56
DOI: 10.1101/2024.12.04.626847

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