Article

Engineered flavonoid disrupts mitochondrial AIF/CHCHD4 complex for targeted cancer therapy

2025-03-15

Abstract excerpt

Oncogenic metabolism depends on multifaceted mechanisms, including bidirectional inter-organelle communication between mitochondria and the nucleus, facilitating cellular adaptation at the transcriptomic, proteomic, and metabolomic levels. The mitochondrial protein complex composed of apoptosis-inducing factor (AIF) and coiled-coil-helix-coiled-coil-helix domain-containing protein 4 (CHCHD4) is essential for this...

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Literature Corpus work: 31cf4a4d-066b-5216-b0e6-b377271d06c8
DOI: 10.1101/2025.03.13.642976

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