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Article

AIF meets the CHCHD4/Mia40-dependent mitochondrial import pathway.

Biochimica et biophysica acta. Molecular basis of disease - 1 Jun 2020

Reinhardt Camille, Arena Giuseppe, Nedara Kenza, Edwards Ruairidh, Brenner Catherine, Tokatlidis Kostas, Modjtahedi Nazanine

Abstract excerpt

In the mitochondria of healthy cells, Apoptosis-Inducing factor (AIF) is required for the optimal functioning of the respiratory chain machinery, mitochondrial integrity, cell survival, and proliferation. In all analysed species, it was revealed that the downregulation or depletion of AIF provokes mainly the post-transcriptional loss of respiratory chain Complex I protein subunits. Recent progress in the field...

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Identifiers

PMID: 32105825
DOI: 10.1016/j.bbadis.2020.165746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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