Article

The human cytomegalovirus-encoded pUS28 antagonizes CD4+ T-cell recognition by targeting CIITA

2023-10-19

Abstract excerpt

<h4>Summary</h4> Human cytomegalovirus (HCMV) is a relevant pathogen especially for individuals with impaired immunity. Harnessing potent immune antagonists, HCMV circumvents sterile immunity. Given that HCMV prevents the upregulation of human leukocyte antigen (HLA)-DP and HLA-DR, we screened a library of HCMV genes by co-expression with the HLA class II (HLA-II)-inducing transcription coordinator class II tra...

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Literature Corpus work: 31cebb84-df90-5725-85d7-d277e3059a5b
DOI: 10.1101/2023.10.17.562683

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