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Ex Vivo Profiling of CD8<sup>+</sup>-T-Cell Responses to Human Cytomegalovirus Reveals Broad and Multispecific Reactivities in Healthy Virus Carriers

11 Apr 2003

Abstract excerpt

Human cytomegalovirus (HCMV) can establish both nonproductive (latent) and productive (lytic) infections. Many of the proteins expressed during these phases of infection could be expected to be targets of the immune response; however, much of our understanding of the CD8(+)-T-cell response to HCMV is mainly based on the pp65 antigen. Very little is known about T-cell control over other antigens expressed during...

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PMID: 12692225
DOI: 10.1128/jvi.77.9.5226-5240.2003

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