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Article

Transcriptional silencing of fetal hemoglobin expression by NonO

23 Jul 2021

Abstract excerpt

Human fetal globin (γ-globin) genes are developmentally silenced after birth, and reactivation of γ-globin expression in adulthood ameliorates symptoms of hemoglobin disorders, such as sickle cell disease (SCD) and β-thalassemia. However, the mechanisms by which γ-globin expression is precisely regulated are still incompletely understood. Here, we found that NonO (non-POU domain-containing octamer-binding...

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PMID: 34379783
DOI: 10.1093/nar/gkab671

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