Article

GCN5-TADA2B in the SAGA complex provide constitutive fine-tuning control of XRCC1 recruitment and focal retention at DNA damage sites

2025-08-28

Abstract excerpt

<h4>ABSTRACT</h4> The scaffolding protein XRCC1 orchestrates base excision repair (BER) and DNA single strand break repair (SSBR) through extensive protein-protein interactions, and its disruption contributes to human neurological diseases such as SCAR26. Recruitment to DNA damage sites has been traditionally understood to depend exclusively on interaction with PARP1 and PARP1 mediated PARylation. Here, we report...

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Literature Corpus work: 31c34c06-a5fb-584b-a9dc-382a0c9fc766
DOI: 10.1101/2025.08.24.672030

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GCN5-TADA2B in the SAGA complex provide constitutive fine-tuning control of XRCC1 recruitment and focal retention at DNA damage sitesDOI 10.1101/2025.08.24.672030Read

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