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Article

Multivalent Binding of p53 to the STAGA Complex Mediates Coactivator Recruitment after UV Damage

4 Feb 2008

Abstract excerpt

The recruitment of transcriptional coactivators, including histone modifying enzymes, is an important step in transcription regulation. A typical activator is thought to interact with several cofactors, presumably in a sequential manner. The common use of several cofactors raises the question of how activators achieve both cofactor selectivity and diversity. Human STAGA is a multiprotein complex with the...

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PMID: 18250150
DOI: 10.1128/mcb.01461-07

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