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DNA methylation is a key determinant of response to targeted and immune checkpoint therapies in metastatic renal cell carcinoma

2024-11-06

Abstract excerpt

The response to targeted therapies and immune checkpoint inhibitors for patients suffering from metastatic clear cell renal cell carcinoma (ccRCC) is heterogeneous and currently not predictable in clinic. In this work, a comprehensive integrated study of 700 ccRCCs profiled by DNA methylation and RNA sequencing showed that the hyper-methylated tumors exhibited a worse prognosis, a higher fraction of cycling tumor...

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Literature Corpus work
a5c87467-271c-5616-8a01-6ec09bde88b1
DOI
10.1101/2024.11.05.622095
Open publication

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DNA methylation is a key determinant of response to targeted and immune checkpoint therapies in metastatic renal cell carcinomaDOI 10.1101/2024.11.05.622095
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