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An enhancer demethylator phenotype tightly associated with immune exhaustion and resistance to immune checkpoint inhibitors in clear-cell renal cell carcinomas

2022-06-03

Abstract excerpt

<title>Abstract</title> <p>Immune checkpoint inhibitors have revolutionized the treatment of patients with clear-cell renal carcinomas. Although, analyses of transcriptome, genetic alterations, and the tumor microenvironment have shed light into mechanisms of response and resistance to these agents, the role of epigenetic alterations in this process remains fully unknown. Herein, we investigated the methylome of...

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Literature Corpus work
af6c6be1-9a7b-509f-ae75-e1db6cfc5ba5
DOI
10.21203/rs.3.rs-1673570/v1
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An enhancer demethylator phenotype tightly associated with immune exhaustion and resistance to immune checkpoint inhibitors in clear-cell renal cell carcinomasDOI 10.21203/rs.3.rs-1673570/v1
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