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Article

Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans.

PLoS genetics - 1 Jan 2013

Heestand Bree N, Shen Yidong, Liu Wei, Magner Daniel B, Storm Nadia, Meharg Caroline, Habermann Bianca, Antebi Adam

Abstract excerpt

Dietary restriction (DR) extends lifespan in a wide variety of species, yet the underlying mechanisms are not well understood. Here we show that the Caenorhabditis elegans HNF4α-related nuclear hormone receptor NHR-62 is required for metabolic and physiologic responses associated with DR-induced longevity. nhr-62 mediates the longevity of eat-2 mutants, a genetic mimetic of dietary restriction, and blunts the...

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Identifiers

PMID: 23935515
DOI: 10.1371/journal.pgen.1003651
PMCID: PMC3723528

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