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A <i>C. elegans</i> model of familial Alzheimer’s disease shows age-dependent synaptic degeneration independent of amyloid β-peptide

2025-07-20

Abstract excerpt

<h4>ABSTRACT</h4> The membrane-embedded γ-secretase complex is involved in the intramembrane cleavage of ∼ 150 substrates. Cleavage of amyloid precursor protein (APP)-derived substrate C99 generates 38-43-residue secreted amyloid β-peptides (Aβ), with the aggregation-prone 42-residue form (Aβ42) particularly implicated in the pathogenesis of Alzheimer’s Disease (AD). However, whether Aβ42 is the primary driver of...

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Literature Corpus work
6a1eab5a-c051-571e-a9d0-57da6a385d31
DOI
10.1101/2025.07.16.665161
Open publication

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A <i>C. elegans</i> model of familial Alzheimer’s disease shows age-dependent synaptic degeneration independent of amyloid β-peptideDOI 10.1101/2025.07.16.665161
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