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BAP1 regulates HSF1 activity and cancer immunity in pancreatic cancer

30 Sept 2024

Abstract excerpt

BACKGROUND: The vast majority of pancreatic cancers have been shown to be insensitive to single-agent immunotherapy. Exploring the mechanisms of immune resistance and implementing combination therapeutic strategies are crucial for PDAC patients to derive benefits from immunotherapy. Deletion of BAP1 occurs in approximately 27% of PDAC patients and is significantly correlated with poor prognosis, but the mechanism...

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PMID: 39350280
DOI: 10.1186/s13046-024-03196-4

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