Article

Endothelial JAK2V617F mutation leads to thrombosis, vasculopathy, and cardiomyopathy in a murine model of myeloproliferative neoplasm

2019-12-31

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Rational</h4> The myeloproliferative neoplasms (MPNs) are clonal hematological malignancies characterized by hematopoietic stem cell expansion and overproduction of mature blood cells. Cardiovascular complications are the leading cause of morbidity and mortality in patients with MPNs. The acquired kinase mutation JAK2V617F plays a central role in these disorders. Mechanisms responsible for...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fb995220-66df-5cd8-8a05-9a1eb2e9d764
DOI: 10.1101/2019.12.31.891721

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Endothelial JAK2V617F mutation leads to thrombosis, vasculopathy, and cardiomyopathy in a murine model of myeloproliferative neoplasmDOI 10.1101/2019.12.31.891721Read

Endothelial JAK2V617F mutation leads to thrombosis, vasculopathy, and cardiomyopathy in a murine model of myeloproliferative neoplasm.Semantic proximity Read

A murine model with JAK2V617F expression in both hematopoietic cells and vascular endothelial cells recapitulates the key features of human myeloproliferative neoplasmSemantic proximity Read

Unlocking the Role of Endothelial MPL Receptor and JAK2V617F Mutation: Insights into Cardiovascular Dysfunction in MPNs and CHIPSemantic proximity Read

Decoding Endothelial MPL and JAK2V617F Mutation: Insight Into Cardiovascular Dysfunction in Myeloproliferative Neoplasms.Semantic proximity Read

[Myeloproliferative neoplasms and vascular diseases].Semantic proximity Read

Targeting TPO/MPL Signaling to Mitigate JAK2V617F-driven Cardiac Microvascular DiseaseSemantic proximity Read

JAK2V <sub>617</sub> F-positive endothelial cells contribute to clotting abnormalities in myeloproliferative neoplasmsSemantic proximity Read

The JAK2V617F-bearing vascular niche promotes clonal expansion in myeloproliferative neoplasms.Semantic proximity Read

Cardiac hypertrophy associated with myeloproliferative neoplasms in JAK2V617F transgenic mice.Semantic proximity Read

[Myeloproliferative neoplasms and endothelial progenitor cells].Semantic proximity Read

JAK2V617F-Positive Endothelial Cells Induce Apoptosis and Release JAK2V617F-Positive MicroparticlesSemantic proximity Read

Vascular events in Korean patients with myeloproliferative neoplasms and their relationship to JAK2 mutation.Semantic proximity Read