Article
Endothelial Cells Harbouring the JAK2V617F Mutation Display Pro-Adherent and Pro-Thrombotic Features.
Thrombosis and haemostasis - 1 Sept 2018
Guadall Anna, Lesteven Elodie, Letort Gil, Awan Toor Sarah, Delord Marc, Pognant Doriane, Brusson Mégane, Verger Emmanuelle, Maslah Nabih, Giraudier Stéphane, Larghero Jerome, Vanneaux Valerie, Chomienne Christine, El Nemer Wassim, Cassinat Bruno, Kiladjian Jean-Jacques
Abstract excerpt
Thromboembolic events are the main cause of mortality in BCR-ABL1-negative myeloproliferative neoplasms (MPNs) but their underlying mechanisms are largely unrecognized. The Janus kinase 2 (JAK2)V617F mutation is the most frequent genetic alteration leading to MPN. Usually found in haematopoietic progenitors and stem cells, this mutation has also been described in endothelial cells (ECs) of MPN patients. In this...
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