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Article

Endothelial JAK2V617F mutation leads to thrombosis, vasculopathy, and cardiomyopathy in a murine model of myeloproliferative neoplasm.

Journal of thrombosis and haemostasis : JTH - 1 Dec 2020

Castiglione Melissa, Jiang Ya-Ping, Mazzeo Christopher, Lee Sandy, Chen Juei-Suei, Kaushansky Kenneth, Yin Wei, Lin Richard Z, Zheng Haoyi, Zhan Huichun

Abstract excerpt

OBJECTIVE: Cardiovascular complications are the leading cause of morbidity and mortality in patients with myeloproliferative neoplasms (MPNs). The acquired kinase mutation JAK2V617F plays a central role in these disorders. Mechanisms responsible for cardiovascular dysfunction in MPNs are not fully understood, limiting the effectiveness of current treatment. Vascular endothelial cells (ECs) carrying the JAK2V617F...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32920974
DOI: 10.1111/jth.15095
PMCID: PMC7756295

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