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Article

Decoding Endothelial MPL and JAK2V617F Mutation: Insight Into Cardiovascular Dysfunction in Myeloproliferative Neoplasms.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2024

Zhang Haotian, Kafeiti Nicholas, Masarik Kyla, Lee Sandy, Yang Xiaoxi, Zheng Haoyi, Zhan Huichun

Abstract excerpt

BACKGROUND: Patients with JAK2V617F-positive myeloproliferative neoplasms (MPNs) and clonal hematopoiesis of indeterminate potential face a significantly elevated risk of cardiovascular diseases. Endothelial cells carrying the JAK2V617F mutation have been detected in many patients with MPN. In this study, we investigated the molecular basis for the high incidence of cardiovascular complications in patients with...

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Source

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Identifiers

PMID: 38989576
DOI: 10.1161/ATVBAHA.124.321008
PMCID: PMC11335084

Genes

MPL
TPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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