Article

The CHIP-clinic as the catalyst of preventive medicine

2024-10-18

Abstract excerpt

Clonal Hematopoiesis of Indeterminate Potential (CHIP) is associated with an increased risk of cardiovascular diseases (CVD) and is a precursor stage to the BCR-ABL negative chronic myeloproliferative neoplasms (MPNs). These diseases are acquired stem cell neoplasms, arising due to mutations in the hematopoietic stem cell. The most prevalent is the JAK2V617F (JAK2) mutation, which potently generates reactive oxyge...

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Literature Corpus work: 63dac806-952e-5f1a-9ec6-4b386fdfcdc2
DOI: 10.3389/frhem.2024.1459154

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