Article

DNA replication stress-induced transcriptome of Human Burkitt’s lymphoma identifies MBD1 as a novel suppressor of <i>BCL6</i> rearrangements in germinal center derived B-lymphomagenesis

2025-03-15

Abstract excerpt

BCL6 is a master transcriptional regulator of germinal center (GC) B cells. BCL6 is frequently translocated at the major translocation cluster (MTC) within intron 1 of the BCL6 locus, a hotspot commonly rearranged in diffuse large B cell lymphomas (DLBCLs). BCL6 amplifications are associated with therapeutic resistance and poor survival outcomes in hematological and solid cancers. However the mechanisms suppres...

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Literature Corpus work: ffd0c306-a17b-5a5c-984c-1e87e6a73e13
DOI: 10.1101/2025.03.13.643172

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