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Intestinal Epithelial PTPN2 Limits Pathobiont Colonization by Immune-Directed Antimicrobial Responses

2024-09-26

Abstract excerpt

<h4>Background and Aims</h4> Loss of activity of the inflammatory bowel disease (IBD) susceptibility gene, protein tyrosine phosphatase non-receptor type 2 ( PTPN2 ), is associated with altered microbiome composition in both human subjects and mice. Further, expansion of the bacterial pathobiont, adherent- invasive E. coli (AIEC), is strongly linked to IBD pathogenesis. The mechanism by which intestinal epithel...

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Literature Corpus work
316d89ee-ca69-5e72-8c32-f5de91ef336e
DOI
10.1101/2024.09.24.614848
Open publication

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Intestinal Epithelial PTPN2 Limits Pathobiont Colonization by Immune-Directed Antimicrobial ResponsesDOI 10.1101/2024.09.24.614848
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